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Working as an intern at the Arkham Asylum, in a classic case of the Florence Nightingale Effect, Dr. Harleen Quinzel fell in love with her patient. After helping him escape from the asylum more than once, Harleen was suspected by the authorities, who revoked her license and placed her in her own cell. She's the only person who's managed to be in a romantic relationship with the Joker on a long term basis, who in turn displays occasional moments of confusion and discomfort which often result in attempts to kill her.